Drug Information

Drug General Information
Drug ID
D09MRL
Former ID
DNCL003490
Drug Name
Pidilizumab
Synonyms
CT-011
Drug Type
Antibody
Indication Diffuse large B-cell lymphoma [ICD9: 200; ICD10:C83.3] Phase 2 [523594], [525398], [542669]
Company
CureTech
Target and Pathway
Target(s) Programmed cell deathe?Y? ligand 1 (PD-L1) Target Info [531481]
KEGG Pathway Cell adhesion molecules (CAMs)
Reactome PD-1 signaling
WikiPathways Costimulation by the CD28 family
References
Ref 523594ClinicalTrials.gov (NCT01420965) Sipuleucel-T, CT-011, and Cyclophosphamide for Advanced Prostate Cancer. U.S. National Institutes of Health.
Ref 525398Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial. J Clin Oncol. 2013 Nov 20;31(33):4199-206.
Ref 542669(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7692).
Ref 531481PD-1 blockade by CT-011, anti-PD-1 antibody, enhances ex vivo T-cell responses to autologous dendritic cell/myeloma fusion vaccine. J Immunother. 2011 Jun;34(5):409-18.

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