Drug Information

Drug General Information
Drug ID
D09NFW
Former ID
DIB005935
Drug Name
Dendritic cell vaccine
Synonyms
Dendritic cell vaccine, University of Bonn; Human telomerase reverse transcriptase (hTERT)-pulsed dendritic cells (cancer), University of Bonn
Drug Type
Vaccine
Indication Ovarian cancer [ICD9: 183; ICD10:C56] Phase 2 [532941]
Company
University of Bonn
Target and Pathway
Target(s) Telomerase reverse transcriptase Target Info [530513]
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Validated targets of C-MYC transcriptional activation
Regulation of Telomerase
IL2 signaling events mediated by PI3K
Regulation of nuclear beta catenin signaling and target gene transcription
HIF-1-alpha transcription factor network
Reactome Formation of the beta-catenin:TCF transactivating complex
References
Ref 532941Dendritic cell-targeted vaccines--hope or hype. Nat Rev Immunol. 2014 Oct;14(10):705-11.
Ref 530513In vitro activation of cytotoxic T-lymphocytes by hTERT-pulsed dendritic cells. J Immunotoxicol. 2009 Dec;6(4):243-8.

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