Drug Information

Drug General Information
Drug ID
D09QWD
Former ID
DIB002291
Drug Name
CEP-37251
Synonyms
ART-010; EGX-010; OVP (bone loss), Peptech; Osteoprotegerin variant protein (bone loss), Arana; Osteoprotegerin variant protein (bone loss), EvoGenix; Osteoprotegerin variant protein (bone loss), Peptech
Indication Bone metastases [ICD9: 198.5; ICD10:C79.51] Phase 1 [523109]
Company
EvoGenix Pty Ltd
Target and Pathway
Target(s) Tumor necrosis factor ligand superfamily member 11 Target Info Inhibitor [551200]
KEGG Pathway Cytokine-cytokine receptor interaction
NF-kappa B signaling pathway
Osteoclast differentiation
Prolactin signaling pathway
Rheumatoid arthritis
NetPath Pathway Leptin Signaling Pathway
TWEAK Signaling Pathway
Pathway Interaction Database IL6-mediated signaling events
Reactome TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
WikiPathways Osteoblast Signaling
Vitamin D Receptor Pathway
Differentiation Pathway
RANKL/RANK Signaling Pathway
Osteoclast Signaling
References
Ref 523109ClinicalTrials.gov (NCT01159873) Single Ascending-Dose Study to Characterize the Safety, Pharmacokinetics, and Pharmacodynamics of CEP-37251 in Healthy Postmenopausal Women. U.S. National Institutes of Health.
Ref 551200This week in therapeutics Cancer. SciBX 3(40); doi:10.1038/scibx.2010.1202. Oct. 14, 2010

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