Drug General Information
Drug ID	D0A8KQ
Former ID	DNCL003601
Drug Name	GSK2256294
Synonyms	GSK-2256294
Indication	Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47]		Phase 1	[532153]
Company	GlaxoSmithKline
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Soluble epoxide hydrolase	Target Info	Modulator	[532153], [532245]
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Peroxisome
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Metapathway biotransformation
	Arachidonate Epoxygenase / Epoxide Hydrolase
	Arachidonic acid metabolism
References
Ref 532153	Soluble epoxide hydrolase inhibition does not prevent cardiac remodeling and dysfunction after aortic constriction in rats and mice. J Cardiovasc Pharmacol. 2013 Apr;61(4):291-301.
Ref 532153	Soluble epoxide hydrolase inhibition does not prevent cardiac remodeling and dysfunction after aortic constriction in rats and mice. J Cardiovasc Pharmacol. 2013 Apr;61(4):291-301.
Ref 532245	In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor. Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:25-31.

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