Drug Information

Drug General Information
Drug ID
D0A8PV
Former ID
DIB020499
Drug Name
NBI-74330
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543101]
Structure
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2D MOL

3D MOL
Formula
C32H27F4N5O3
InChI
InChI=1S/C32H27F4N5O3/c1-3-44-24-11-9-23(10-12-24)41-30(39-29-25(31(41)43)7-5-15-38-29)20(2)40(19-22-6-4-14-37-18-22)28(42)17-21-8-13-27(33)26(16-21)32(34,35)36/h4-16,18,20H,3,17,19H2,1-2H3
InChIKey
XMRGQUDUVGRCBS-UHFFFAOYSA-N
PubChem Compound ID
10167713
PubChem Substance ID
15160849, 26720030, 40151866, 46535269, 77601360, 135650695, 172919328, 240025359, 241377037, 249691216, 252158142
Target and Pathway
Target(s) C-X-C chemokine receptor type 3 Target Info Antagonist [536059]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database CXCR3-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 543101(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 839).
Ref 536059Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist. J Pharmacol Exp Ther. 2005 Jun;313(3):1263-71. Epub 2005 Mar 10.

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