Drug Information

Drug General Information
Drug ID
D0B6IZ
Former ID
DCL000604
Drug Name
R1678
Synonyms
R-1678; RG-1678
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Phase 3 [523242], [542547]
Company
Roche
Structure
Download
2D MOL

3D MOL
Formula
C21H20F7N3O4S
InChI
InChI=1S/C21H20F7N3O4S/c1-12(20(23,24)25)35-17-4-3-14(36(2,33)34)10-15(17)19(32)31-7-5-30(6-8-31)18-16(22)9-13(11-29-18)21(26,27)28/h3-4,9-12H,5-8H2,1-2H3/t12-/m0/s1
InChIKey
YUUGYIUSCYNSQR-LBPRGKRZSA-N
PubChem Compound ID
24946690
PubChem Substance ID
56244412, 57478254, 99431594, 104143952, 135256494, 135626904, 137127970, 141157826, 144116333, 160647105, 163117751, 163620714, 165248472, 172919533, 176246996, 184816751, 204430544, 215784659, 223365882, 223401879, 226869785, 245521130, 249865394, 252065990, 252449063
Target and Pathway
Target(s) Sodium- and chloride-dependent glycine transporter 1 Target Info Blocker [551607]
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways NRF2 pathway
References
Ref 523242ClinicalTrials.gov (NCT01235559) A Study of RO4917838 (Bitopertin) in Patients With Sub-optimally Controlled Symptoms of Schizophrenia (WN25305). U.S. National Institutes of Health.
Ref 542547(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7546).
Ref 551607Clinical pipeline report, company report or official report of Roche (2009).

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