Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0B6MQ
|
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| Former ID |
DIB020744
|
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| Drug Name |
polyIC
|
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| Synonyms |
poly(I:C); polyinosine:polycytidylic acid; polyinosine-polycytosine
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [468139] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C19H27N7O16P2
|
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| InChI |
InChI=1S/C10H13N4O8P.C9H14N3O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)
|
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| InChIKey |
ACEVNMQDUCOKHT-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Toll-like receptor 3 | Target Info | Agonist | [526173] | |
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Toll receptor signaling pathway | ||||
| Pathway Interaction Database | Endogenous TLR signaling | ||||
| Reactome | Ligand-dependent caspase activation | ||||
| MyD88-independent TLR3/TLR4 cascade | |||||
| Trafficking and processing of endosomal TLR | |||||
| RIP-mediated NFkB activation via ZBP1 | |||||
| TRIF-mediated programmed cell death | |||||
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | |||||
| IKK complex recruitment mediated by RIP1 | |||||
| TRAF6 mediated induction of TAK1 complex | |||||
| References | |||||
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