Drug Information

Drug General Information
Drug ID
D0CQ1J
Former ID
DNC000051
Drug Name
2'-aminoimidazolylmethyluracils
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535670]
Structure
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2D MOL

3D MOL
Formula
C8H10ClN5O2
Canonical SMILES
C1=CN(C(N1)N)CC2=C(C(=O)NC(=O)N2)Cl
InChI
1S/C8H10ClN5O2/c9-5-4(12-8(16)13-6(5)15)3-14-2-1-11-7(14)10/h1-2,7,11H,3,10H2,(H2,12,13,15,16)
InChIKey
VDNGDZIPDSUEKT-UHFFFAOYSA-N
PubChem Compound ID
56603742
PubChem Substance ID
134339596
Target and Pathway
Target(s) Thymidine phosphorylase Target Info Inhibitor [535670]
BioCyc Pathway Pyrimidine deoxyribonucleosides degradation
KEGG Pathway Pyrimidine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Bladder cancer
NetPath Pathway TSH Signaling Pathway
PathWhiz Pathway Pyrimidine Metabolism
WikiPathways Bladder Cancer
Metabolism of nucleotides
Fluoropyrimidine Activity
References
Ref 535670Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase. J Med Chem. 2003 Jan 16;46(2):207-9.
Ref 535670Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase. J Med Chem. 2003 Jan 16;46(2):207-9.

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