Drug General Information
Drug ID	D0DN1I
Former ID	DIB014085
Drug Name	JTT-551
Indication	Type 2 diabetes [ICD9: 250; ICD10:E11]		Terminated	[532867]
Company	Japan Tobacco Inc
Structure		Download 2D MOL
Target and Pathway
Target(s)	Protein tyrosine phosphatase-1B	Target Info	Inhibitor	[532867]
KEGG Pathway	Adherens junction
	Insulin signaling pathway
NetPath Pathway	FSH Signaling Pathway
PANTHER Pathway	Cadherin signaling pathway
Pathway Interaction Database	Insulin Pathway
	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
	Signaling events mediated by PTP1B
	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	Signaling events mediated by TCPTP
	IGF1 pathway
	EGF receptor (ErbB1) signaling pathway
	Posttranslational regulation of adherens junction stability and dissassembly
	PDGFR-beta signaling pathway
	N-cadherin signaling events
Reactome	Integrin alphaIIb beta3 signaling
	Regulation of IFNG signaling
	Regulation of IFNA signaling
	Growth hormone receptor signaling
WikiPathways	Insulin Signaling
	Growth hormone receptor signaling
	Leptin signaling pathway
	Interferon gamma signaling
	Interferon alpha/beta signaling
	Integrin alphaIIb beta3 signaling
References
Ref 532867	Pharmacological effects of JTT-551, a novel protein tyrosine phosphatase 1B inhibitor, in diet-induced obesity mice. J Diabetes Res. 2014;2014:680348.
Ref 532867	Pharmacological effects of JTT-551, a novel protein tyrosine phosphatase 1B inhibitor, in diet-induced obesity mice. J Diabetes Res. 2014;2014:680348.

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