Drug General Information
Drug ID	D0E6BA
Former ID	DNC000045
Drug Name	2,3,7-trichloro-5-nitroquinoxaline (TNQX)
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[535725]
Structure		Download 2D MOL 3D MOL
Formula	C8H2Cl3N3O2
Canonical SMILES	C1=C(C=C2C(=C1[N+](=O)[O-])N=C(C(=N2)Cl)Cl)Cl
InChI	1S/C8H2Cl3N3O2/c9-3-1-4-6(5(2-3)14(15)16)13-8(11)7(10)12-4/h1-2H
InChIKey	DUBINERALUDRHX-UHFFFAOYSA-N
PubChem Compound ID	10378848
PubChem Substance ID	15393584, 34098465, 57374634, 76627286, 134339591, 245903729, 249553389
Target and Pathway
Target(s)	Telomerase reverse transcriptase	Target Info	Inhibitor	[535725]
NetPath Pathway	IL2 Signaling Pathway
Pathway Interaction Database	Validated targets of C-MYC transcriptional activation
	Regulation of Telomerase
	IL2 signaling events mediated by PI3K
	Regulation of nuclear beta catenin signaling and target gene transcription
	HIF-1-alpha transcription factor network
Reactome	Formation of the beta-catenin:TCF transactivating complex
References
Ref 535725	Identification of a quinoxaline derivative that is a potent telomerase inhibitor leading to cellular senescence of human cancer cells. Biochem J. 2003 Jul 15;373(Pt 2):523-9.
Ref 535725	Identification of a quinoxaline derivative that is a potent telomerase inhibitor leading to cellular senescence of human cancer cells. Biochem J. 2003 Jul 15;373(Pt 2):523-9.

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