Drug Information

Drug General Information
Drug ID
D0EK9K
Former ID
DIB004991
Drug Name
Sch-900875
Synonyms
CXCR3 antagonists (inflammatory diseases); Sch-900875; CXCR3 antagonists (inflammatory diseases), Schering-Plough/Ligand/Merck & Co
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Investigative [543922]
Company
Ligand Pharmaceuticals Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
C(=O)(c1cnc(c(c1)Cl)N1C[C@@H](N(CC1)C1CCN(CC1)Cc1c(cc(c<br />c1)Cl)F)CC)NCC
Target and Pathway
Target(s) C-X-C chemokine receptor type 3 Target Info Antagonist [543922]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database CXCR3-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 543922(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 70).
Ref 543922(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 70).

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