Drug Information

Drug General Information
Drug ID
D0F2JS
Former ID
DCL000085
Drug Name
CHR-2797
Synonyms
Tosedostat; BB-76163; Tosedostat, CHR2797, CHR-2797
Drug Type
Small molecular drug
Indication Acute myeloid leukemia [ICD9: 205; ICD10:C92.0] Phase 2 [548127]
Therapeutic Class
Anticancer Agents
Company
Chroma Therape.
Structure
Download
2D MOL

3D MOL
Formula
C21H30N2O6
Canonical SMILES
CC(C)CC(C(C(=O)NO)O)C(=O)NC(C1=CC=CC=C1)C(=O)OC2CCCC2
InChI
1S/C21H30N2O6/c1-13(2)12-16(18(24)20(26)23-28)19(25)22-17(14-8-4-3-5-9-14)21(27)29-15-10-6-7-11-15/h3-5,8-9,13,15-18,24,28H,6-7,10-12H2,1-2H3,(H,22,25)(H,23,26)/t16-,17+,18+/m1/s1
InChIKey
FWFGIHPGRQZWIW-SQNIBIBYSA-N
PubChem Compound ID
15547703
PubChem Substance ID
50094128, 85197633, 85886759, 99437203, 124757313, 125164117, 126666918, 135264670, 135626746, 135698865, 135727437, 136348239, 136367534, 136367991, 137276019, 140102605, 144115826, 152344443, 160708510, 162037644, 162202731, 163126223, 164023428, 164194097, 164765662, 177748695, 184824039, 198964464, 204377611, 223665363, 223704697, 241054287, 241376540, 243220305, 252157386, 252451524
Target and Pathway
Target(s) Puromycin-sensitive aminopeptidase Target Info Inhibitor [536813]
Reactome Antigen processing: Ubiquitination & Proteasome degradation
References
Ref 548127Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022187)
Ref 536813CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. Cancer Res. 2008 Aug 15;68(16):6669-79.

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