Drug General Information
Drug ID	D0G1DS
Former ID	DNC006293
Drug Name	5-chloro-6-hydrazinouracil hydrochloride
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527920]
Structure		Download 2D MOL 3D MOL
Formula	C4H6Cl2N4O2
Canonical SMILES	C1(=C(NC(=O)NC1=O)NN)Cl.Cl
InChI	1S/C4H5ClN4O2.ClH/c5-1-2(9-6)7-4(11)8-3(1)10;/h6H2,(H3,7,8,9,10,11);1H
InChIKey	CEUAYFMFBGNGQD-UHFFFAOYSA-N
PubChem Compound ID	45263377
Target and Pathway
Target(s)	Thymidine phosphorylase	Target Info	Inhibitor	[527920]
BioCyc Pathway	Pyrimidine deoxyribonucleosides degradation
KEGG Pathway	Pyrimidine metabolism
	Drug metabolism - other enzymes
	Metabolic pathways
	Bladder cancer
NetPath Pathway	TSH Signaling Pathway
PathWhiz Pathway	Pyrimidine Metabolism
WikiPathways	Bladder Cancer
	Metabolism of nucleotides
	Fluoropyrimidine Activity
References
Ref 527920	Bioorg Med Chem Lett. 2006 Mar 1;16(5):1335-7. Epub 2005 Dec 5.Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase.
Ref 527920	Bioorg Med Chem Lett. 2006 Mar 1;16(5):1335-7. Epub 2005 Dec 5.Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase.

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