Drug Information

Drug General Information
Drug ID
D0G2MR
Former ID
DIB013011
Drug Name
ProstaVac
Synonyms
ProstaVac; Pox virus vector prostate specific antigen vaccine (benign prostatic hyperplasia/prostatitis); Pox virus vector prostate specific antigen vaccine (benign prostatic hyperplasia/prostatitis), AmVac
Drug Type
Vaccine
Indication Prostate hyperplasia [ICD10:N40] Phase 3 [544259]
Company
AmVac AG
Target and Pathway
Target(s) Prostate specific antigen Target Info [543613]
KEGG Pathway Pathways in cancer
Prostate cancer
Pathway Interaction Database Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
FOXA1 transcription factor network
Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways Prostate Cancer
Androgen receptor signaling pathway
References
Ref 544259Prostvac-VF: a vector-based vaccine targeting PSA in prostate cancer. Expert Opin Investig Drugs. 2009 July; 18(7): 1001-1011.
Ref 543613(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2373).

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