Drug Information

Drug General Information
Drug ID
D0H4TQ
Former ID
DAP001248
Drug Name
Thyrotropin Alfa
Indication Thyroid cancer diagnosis [ICD9: 193; ICD10:C73] Approved [538556]
Therapeutic Class
Diagnostic Agents
Formula
C975H1513N267O304S26
CAS Number
CAS 9002-71-5
SuperDrug ATC ID
H01AB01; V04CJ01
Target and Pathway
Target(s) Thyrotropin receptor Target Info Binder [536852], [537604]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Thyroid hormone synthesis
Autoimmune thyroid disease
NetPath Pathway Wnt Signaling Pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Hormone ligand-binding receptors
G alpha (s) signalling events
WikiPathways Peptide GPCRs
TSH signaling pathway
Thyroxine (Thyroid Hormone) Production
GPCR ligand binding
GPCR downstream signaling
References
Ref 538556FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020898.
Ref 536852Diagnosis of poorly differentiated thyroid cancer with radioiodine scanning after thyrotropin alfa stimulation. N Engl J Med. 2008 Sep 18;359(12):1295-7.
Ref 537604Pharmacological profiles and clinical effects of recombinant human thyrotropin alfa (Thyrogen) Intramuscular Injection 0.9 mg). Nippon Yakurigaku Zasshi. 2009 Jul;134(1):28-34.

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