Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0H9SX
|
||||
| Former ID |
DIB014929
|
||||
| Drug Name |
Daporinad
|
||||
| Synonyms |
APO-866; FK-866; WK-175
|
||||
| Drug Type |
Small molecular drug
|
||||
| Company |
Astellas Pharma GmbH
|
||||
| Structure |
|
Download2D MOL |
|||
| Formula |
C24H29N3O2
|
||||
| InChI |
InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
|
||||
| InChIKey |
KPBNHDGDUADAGP-VAWYXSNFSA-N
|
||||
| CAS Number |
CAS 201034-75-5
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID |
11538981, 14780790, 17192219, 43526910, 46394178, 46394209, 53790372, 75004561, 103699847, 104503566, 114781462, 131341969, 135267025, 135290575, 135351996, 135697735, 137236278, 141035236, 144115979, 152133995, 152159605, 152344381, 163621115, 163685700, 163686454, 163981454, 164194112, 172919044, 175426320, 175607620, 177748701, 186014805, 187071987, 198977556, 204372575, 221121841, 221121846, 223366078, 249814512, 251910568, 252160019, 252215425, 252471670
|
||||
| Target and Pathway | |||||
| Target(s) | Nicotinamide phosphoribosyltransferase | Target Info | Inhibitor | [529259] | |
| BioCyc Pathway | NAD salvage | ||||
| KEGG Pathway | Nicotinate and nicotinamide metabolism | ||||
| Metabolic pathways | |||||
| PathWhiz Pathway | Nicotinate and Nicotinamide Metabolism | ||||
| References | |||||
| Ref 529259 | Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem Biophys Res Commun. 2008 Mar 21;367(4):799-804. | ||||
| Ref 542710 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7745). | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.