Drug General Information
Drug ID	D0I7IF
Former ID	DNC007870
Drug Name	6-bromo-5-phenylpyrimidine-2,4(1H,3H)-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529120]
Structure		Download 2D MOL 3D MOL
Formula	C10H7BrN2O2
Canonical SMILES	C1=CC=C(C=C1)C2=C(NC(=O)NC2=O)Br
InChI	1S/C10H7BrN2O2/c11-8-7(6-4-2-1-3-5-6)9(14)13-10(15)12-8/h1-5H,(H2,12,13,14,15)
InChIKey	XSEDFSJHHTXVPL-UHFFFAOYSA-N
PubChem Compound ID	23648528
Target and Pathway
Target(s)	Thymidine phosphorylase	Target Info	Inhibitor	[529120]
BioCyc Pathway	Pyrimidine deoxyribonucleosides degradation
KEGG Pathway	Pyrimidine metabolism
	Drug metabolism - other enzymes
	Metabolic pathways
	Bladder cancer
NetPath Pathway	TSH Signaling Pathway
PathWhiz Pathway	Pyrimidine Metabolism
WikiPathways	Bladder Cancer
	Metabolism of nucleotides
	Fluoropyrimidine Activity
References
Ref 529120	J Med Chem. 2007 Nov 29;50(24):6016-23. Epub 2007 Oct 27.Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase.
Ref 529120	J Med Chem. 2007 Nov 29;50(24):6016-23. Epub 2007 Oct 27.Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase.

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