Drug Information

Drug General Information
Drug ID
D0K0ZK
Former ID
DIB003556
Drug Name
ADX-63365
Synonyms
MGluR5 PAM; ADX-4; ADX-47273; ADX-50938; MGluR5 positive modulators, Addex; ADX-4 program, Addex
Drug Type
Small molecular drug
Indication Central nervous system disease [ICD10:G00-G99] Investigative [538898]
Company
Addex Pharmaceuticals SA
Structure
Download
2D MOL

3D MOL
Formula
C20H17F2N3O2
InChI
InChI=1S/C20H17F2N3O2/c21-16-7-3-13(4-8-16)18-23-19(27-24-18)15-2-1-11-25(12-15)20(26)14-5-9-17(22)10-6-14/h3-10,15H,1-2,11-12H2/t15-/m0/s1
InChIKey
VXQCCZHCFBHTTD-HNNXBMFYSA-N
PubChem Compound ID
11383075
PubChem Substance ID
16477027, 23536103, 42462271, 75375724, 99431602, 103489132, 104071520, 135649898, 135693358, 135723349, 136348852, 136946586, 141239375, 144115548, 144240227, 162011599, 162202778, 162219991, 172650451, 174007047, 174530985, 186009058, 189561517, 198977704, 226552698, 242585865, 244602588, 252110345, 252450460
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Modulator [543750]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538898(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1420).
Ref 543750(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 293).

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