Drug Information

Drug General Information
Drug ID
D0K1LJ
Former ID
DIB009878
Drug Name
Ad5-TRAIL
Synonyms
Ad5-TRAIL adenoviral gene therapy (prostate cancer), University of Iowa
Indication Prostate cancer [ICD9: 185; ICD10:C61] Phase 1 [551576]
Company
University of Iowa
Target and Pathway
Target(s) TNF related apoptosis inducing ligand Target Info Modulator [528010]
KEGG Pathway Cytokine-cytokine receptor interaction
FoxO signaling pathway
Apoptosis
Natural killer cell mediated cytotoxicity
Measles
Influenza A
NetPath Pathway IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TNFalpha Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
Pathway Interaction Database TRAIL signaling pathway
Caspase Cascade in Apoptosis
Reactome Ligand-dependent caspase activation
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signaling
WikiPathways Apoptosis
Extrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
TP53 Network
References
Ref 551576Phase I trial of Ad5-TRAIL-mediated gene transfer in men with locally-confined prostate cancer prior to planned radical prostatectomy. The Journal of Urology. 04/2008; 179(4):396-396.
Ref 528010Enhancement of Ad5-TRAIL cytotoxicity against renal cell carcinoma with histone deacetylase inhibitors. Cancer Gene Ther. 2006 Jun;13(6):628-32.

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