Drug General Information
Drug ID
D0K1UF
Former ID
DIB016089
Drug Name
Saliphenylhalamide
Synonyms
RTA-203; Saliphenylhalamide (cancer); Saliphenylhalamide (cancer), Reata; V-ATPase inhibitor (cancer), Reata; Vacuolar H+-ATPase inhibitors (anticancer), Reata
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543965]
Company
Reata Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL

Formula
C28H29NO5
Canonical SMILES
c1ccc2c(c1O)C(=O)O[C@H](C[C@H]([C@H](C/C=C/C2)C)O)C/C=C<br />/NC(=O)C#Cc1ccccc1
PubChem Compound ID
Target and Pathway
Target(s) Potassium-transporting ATPase alpha chain 1 Target Info Inhibitor [543965]
KEGG Pathway Oxidative phosphorylation
Collecting duct acid secretion
Gastric acid secretion
PathWhiz Pathway Gastric Acid Production
Reactome Ion transport by P-type ATPases
WikiPathways Iron uptake and transport
Secretion of Hydrochloric Acid in Parietal Cells
References
Ref 543965(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 849).
Ref 543965(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 849).

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