Drug Information

Drug General Information
Drug ID
D0K3LO
Former ID
DNCL003322
Drug Name
Romosozumab
Synonyms
AMG 785
Drug Type
Antibody
Indication Postmenopausal osteoporosis [ICD9: 733; ICD10:M80-M81] Phase 3 [523960], [542966]
Company
Amgen
Target and Pathway
Target(s) Sclerostin Target Info [532609]
KEGG Pathway Wnt signaling pathway
NetPath Pathway TWEAK Signaling Pathway
Reactome TCF dependent signaling in response to WNT
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
References
Ref 523960ClinicalTrials.gov (NCT01631214) Study to Determine the Efficacy and Safety of Romosozumab in the Treatment of Postmenopausal Women With Osteoporosis. U.S. National Institutes of Health.
Ref 542966(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8092).
Ref 532609Romosozumab in postmenopausal women with low bone mineral density. N Engl J Med. 2014 Jan 30;370(5):412-20.

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