Drug Information

Drug General Information
Drug ID
D0K7NI
Former ID
DIB004503
Drug Name
ABT-RTA-408
Indication Non-small cell lung cancer [ICD10:C33-C34] Phase 2 [524762]
Company
Abbvie; reata pharmaceuticals
Target and Pathway
Target(s) Nuclear factor erythroid 2-related factor 2 Target Info Modulator [550508]
KEGG Pathway Protein processing in endoplasmic reticulum
NetPath Pathway IL5 Signaling Pathway
WikiPathways Oxidative Stress
Transcriptional activation by NRF2
NRF2 pathway
Nuclear Receptors Meta-Pathway
Aryl Hydrocarbon Receptor Pathway
Mesodermal Commitment Pathway
Aryl Hydrocarbon Receptor
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Arylhydrocarbon receptor (AhR) signaling pathway
References
Ref 524762ClinicalTrials.gov (NCT02142959) RTA 408 Lotion in Patients at Risk for Radiation Dermatitis - PRIMROSE. U.S. National Institutes of Health.
Ref 550508National Cancer Institute Drug Dictionary (drug id 756624).

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