Drug Information

Drug General Information
Drug ID
D0KG5D
Former ID
DNCL002671
Drug Name
Mapatumumab
Drug Type
Monoclonal antibody
Indication Advanced hepatocellular carcinoma; Non-small cell lung cancer [ICD9: 155; ICD10:C22.0, C33-C34] Phase 2 [521614]
Company
Human Genome Sciences
CAS Number
CAS 658052-09-6
Target and Pathway
Target(s) Tumor necrosis factor receptor superfamily member 10A Target Info Modulator [550408]
KEGG Pathway Cytokine-cytokine receptor interaction
Apoptosis
Natural killer cell mediated cytotoxicity
Measles
Influenza A
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
p53 pathway
Pathway Interaction Database TRAIL signaling pathway
Direct p53 effectors
Caspase Cascade in Apoptosis
Reactome Ligand-dependent caspase activation
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signaling
WikiPathways miR-targeted genes in lymphocytes - TarBase
Apoptosis Modulation and Signaling
References
Ref 521614ClinicalTrials.gov (NCT00094848) Study of TRM-1 (TRAIL-R1 Monoclonal Antibody) in Subjects With Relapsed or Refractory Non-Hodgkin's Lymphoma (NHL). U.S. National Institutes of Health.
Ref 550408National Cancer Institute Drug Dictionary (drug id 486626).

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