Drug Information

Drug General Information
Drug ID
D0KL4J
Former ID
DAP000727
Drug Name
Rabeprazole
Synonyms
Dexrabeprazole; Eraloc; Rebeprazole sodium; CL23619; LY307640; Aciphex (TN); Eraloc (TN); Pariet (TN); Rabeprazole (INN); Rabeprazole [BAN:INN]; Rabeprazole [INN:BAN]; Rablet (TN); 2-(((4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole; 2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole; 2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole; 2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl]-1H-benzimidazole
Drug Type
Small molecular drug
Indication Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Approved [535862], [542311]
Therapeutic Class
Antiulcer Agents
Company
Eisai; Johnson & Johnson
Structure
Download
2D MOL

3D MOL
Formula
C18H21N3O3S
InChI
InChI=1S/C18H21N3O3S/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21)
InChIKey
YREYEVIYCVEVJK-UHFFFAOYSA-N
CAS Number
CAS 117976-89-3
PubChem Compound ID
5029
PubChem Substance ID
10066, 5392621, 7980480, 8153096, 14828218, 29224100, 46386636, 46506366, 49681560, 49742702, 50064224, 50769860, 57288826, 57322572, 85174502, 92308674, 93166177, 96025149, 103370406, 104029616, 104308073, 118212884, 124659135, 125338815, 126525321, 126591137, 126655846, 126670688, 126670689, 129836330, 131295768, 134338014, 135040318, 137018746, 142316515, 142318546, 142519546, 152034678, 160825170, 160964463, 162022428, 163092473, 163384417, 164339280, 164787748, 166650031, 170500544, 172080531, 178103864, 179116873
ChEBI ID
ChEBI:8768
SuperDrug ATC ID
A02BC04
SuperDrug CAS ID
cas=117976893
Target and Pathway
Target(s) Potassium-transporting ATPase alpha chain 1 Target Info Inhibitor [534917], [534918]
KEGG Pathway Oxidative phosphorylation
Collecting duct acid secretion
Gastric acid secretion
PathWhiz Pathway Gastric Acid Production
Reactome Ion transport by P-type ATPases
WikiPathways Iron uptake and transport
Secretion of Hydrochloric Acid in Parietal Cells
References
Ref 535862An overview of proton pump inhibitors. Gastroenterol Nurs. 2003 Sep-Oct;26(5):182-90.
Ref 542311(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7290).
Ref 534917Review article: pharmacokinetic concerns in the selection of anti-ulcer therapy. Aliment Pharmacol Ther. 1999 Oct;13 Suppl 5:11-6.
Ref 534918Review article: rabeprazole's tolerability profile in clinical trials. Aliment Pharmacol Ther. 1999 Oct;13 Suppl 5:17-23.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.