Drug Information

Drug General Information
Drug ID
D0LT0U
Former ID
DIB007067
Drug Name
ORG-25935
Synonyms
Cis-N-(6-Methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)-N-methylglycine hydrochloride
Drug Type
Small molecular drug
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Phase 2 [522391]
Structure
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2D MOL

3D MOL
Formula
C21H26ClNO3
Canonical SMILES
CN(CC1CCC2=C(C1C3=CC=CC=C3)C=CC(=C2)OC)CC(=O)O.Cl
InChI
1S/C21H25NO3.ClH/c1-22(14-20(23)24)13-17-9-8-16-12-18(25-2)10-11-19(16)21(17)15-6-4-3-5-7-15;/h3-7,10-12,17,21H,8-9,13-14H2,1-2H3,(H,23,24);1H/t17-,21+;/m1./s1
InChIKey
SDTLOODMXMDJFX-JKSHRDEXSA-N
CAS Number
CAS 258887-13-7
PubChem Compound ID
11740218
PubChem Substance ID
16846635, 42782279, 56255780, 77279174, 135264284, 135653578, 144116316, 172650761, 198943844, 252160255
Target and Pathway
Target(s) Sodium- and chloride-dependent glycine transporter 1 Target Info Inhibitor [532527], [532672]
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways NRF2 pathway
References
Ref 522391ClinicalTrials.gov (NCT00725725) Org 25935 Versus Placebo as Augmentation to Cognitive-behavioral Therapy to Treat Panic Disorder (P05705AM3)(TERMINATED). U.S. National Institutes of Health.
Ref 532527Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain. Nat Rev Drug Discov. 2013 Nov;12(11):866-85.
Ref 532672The selective glycine uptake inhibitor org 25935 as an adjunctive treatment to atypical antipsychotics in predominant persistent negative symptoms of schizophrenia: results from the GIANT trial. J Clin Psychopharmacol. 2014 Apr;34(2):190-8.

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