Drug Information

Drug General Information
Drug ID
D0MC5J
Former ID
DIB020637
Drug Name
PACAP-27
Synonyms
pituitary adenylate cyclase activating polypeptide-27
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539430]
Structure
Download
2D MOL
Formula
C142H224N40O39S
InChI
InChI=1S/C142H224N40O39S/c1-16-75(10)113(179-108(191)66-156-120(201)102(63-109(192)193)173-135(216)104(67-183)176-119(200)88(146)62-84-65-153-70-157-84)139(220)174-101(58-80-28-18-17-19-29-80)133(214)182-114(79(14)186)140(221)175-103(64-110(194)195)132(213)178-106(69-185)136(217)172-100(61-83-39-45-87(189)46-40-83)131(212)177-105(68-184)134(215)164-93(34-27-54-155-142(151)152)126(207)170-98(59-81-35-41-85(187)42-36-81)129(210)163-92(33-26-53-154-141(149)150)124(205)161-89(30-20-23-50-143)122(203)165-94(47-48-107(147)190)127(208)166-95(49-55-222-15)121(202)159-78(13)118(199)180-111(73(6)7)137(218)167-91(32-22-25-52-145)123(204)162-90(31-21-24-51-144)125(206)171-99(60-82-37-43-86(188)44-38-82)130(211)169-97(57-72(4)5)128(209)160-76(11)116(197)158-77(12)117(198)181-112(74(8)9)138(219)168-96(115(148)196)56-71(2)3/h17-19,28-29,35-46,65,70-79,88-106,111-114,183-189H,16,20-27,30-34,47-64,66-69,143-146H2,1-15H3,(H2,147,190)(H2,148,196)(H,153,157)(H,156,201)(H,158,197)(H,159,202)(H,160,209)(H,161,205)(H,162,204)(H,163,210)(H,164,215)(H,165,203)(H,166,208)(H,167,218)(H,168,219)(H,169,211)(H,170,207)(H,171,206)(H,172,217)(H,173,216)(H,174,220)(H,175,221)(H,176,200)(H,177,212)(H,178,213)(H,179,191)(H,180,199)(H,181,198)(H,182,214)(H,192,193)(H,194,195)(H4,149,150,154)(H4,151,152,155)
InChIKey
RZGBUJXSKLDAFE-UHFFFAOYSA-N
PubChem Compound ID
16133238
PubChem Substance ID
7478461, 24891501, 40666770, 54212961, 57380213, 135651849
Target and Pathway
Target(s) VIP 2 receptor Target Info Agonist [528390]
Vasoactive intestinal polypeptide receptor 1 Target Info Agonist [528390]
PAC1 receptor Target Info Agonist [528390]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
NetPath Pathway TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
Pathway Interaction Database Glucocorticoid receptor regulatory network
Reactome G alpha (s) signalling eventsR-HSA-418555:G alpha (s) signalling events
WikiPathways SIDS Susceptibility Pathways
GPCRs, Class B Secretin-like
GPCR ligand binding
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
GPCR downstream signaling
References
Ref 539430(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2257).
Ref 528390A systematic comparison of intracellular cyclic AMP and calcium signalling highlights complexities in human VPAC/PAC receptor pharmacology. Neuropharmacology. 2006 Nov;51(6):1086-98. Epub 2006 Aug 23.

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