Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0MW7S
|
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| Former ID |
DIB005929
|
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| Drug Name |
Lexatumumab
|
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| Synonyms |
HGS-ETR2; TRAIL receptor-2 monoclonal antibodies (cancer), HGS/CAT; TRAIL-R2 mAbs (cancer), Human Genome Sciences/Cambridge Antibody Technology; TNF-related apoptosis-inducing ligand receptor-2 mAbs (cancer), HGS/CAT
|
||||
| Drug Type |
Antibody
|
||||
| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Phase 2 | [528631] | ||
| Company |
Cambridge Antibody Technology Group plc
|
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| CAS Number |
CAS 845816-02-6
|
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| Target and Pathway | |||||
| Target(s) | Tumor necrosis factor receptor superfamily member 10B | Target Info | [550413] | ||
| NetPath Pathway | TCR Signaling Pathway | ||||
| TNFalpha Signaling Pathway | |||||
| PANTHER Pathway | Apoptosis signaling pathway | ||||
| p53 pathway | |||||
| Pathway Interaction Database | TRAIL signaling pathway | ||||
| Direct p53 effectors | |||||
| Caspase Cascade in Apoptosis | |||||
| WikiPathways | DNA Damage Response | ||||
| Apoptosis-related network due to altered Notch3 in ovarian cancer | |||||
| Apoptosis | |||||
| miR-targeted genes in squamous cell - TarBase | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| miR-targeted genes in epithelium - TarBase | |||||
| Extrinsic Pathway for Apoptosis | |||||
| Apoptosis Modulation and Signaling | |||||
| miRNA Regulation of DNA Damage Response | |||||
| References | |||||
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