Drug Information

Drug General Information
Drug ID
D0N1SH
Former ID
DIB000626
Drug Name
VX-15
Synonyms
VX-15/2503; Plexin B1 antagonist (autoimmune disease/cancer), Vaccinex; Anti-CD100 MAb (autoimmune disease/cancer), Vaccinex;Anti-semaphorin 4D monoclonal antibody (autoimmune disease/cancer), Vaccinex
Drug Type
Antibody
Indication Multiple scierosis [ICD9: 340; ICD10:G35] Phase 1 [524181]
Company
Vaccinex Inc
Target and Pathway
Target(s) Semaphorin-4D Target Info [533327]
KEGG Pathway Axon guidance
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Axon guidance mediated by semaphorins
Reactome Sema4D mediated inhibition of cell attachment and migration
Sema4D induced cell migration and growth-cone collapse
Other semaphorin interactions
WikiPathways Semaphorin interactions
References
Ref 524181ClinicalTrials.gov (NCT01764737) Evaluation of Safety, Tolerability, and PK of VX15/2503 In Patients With MS. U.S. National Institutes of Health.
Ref 533327Safety, Pharmacokinetics and Pharmacodynamics of a Humanized anti-Semaphorin 4D Antibody, in a First-In-Human Study of Patients with Advanced Solid Tumors. Clin Cancer Res. 2015 Oct 7. pii: clincanres.0431.2015.

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