Drug General Information
Drug ID	D0O0JH
Former ID	DIB010035
Drug Name	F-12509A
Indication	Arteriosclerosis [ICD9: 440; ICD10:I70]		Terminated	[525833]
Company	Sankyo Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C1(=C(C(=O)C=C(C1=O)O)O)C[C@@H]1[C@@]2([C@H](C(CCC2)(C)<br />C)CCC1=C)C
CAS Number	CAS 191608-64-7
Target and Pathway
Target(s)	Sphingosine kinase	Target Info	Inhibitor	[525833]
BioCyc Pathway	Sphingosine and sphingosine-1-phosphate metabolism
KEGG Pathway	Sphingolipid metabolism
	Metabolic pathways
	Calcium signaling pathway
	Sphingolipid signaling pathway
	VEGF signaling pathway
	Fc gamma R-mediated phagocytosis
	Tuberculosis
NetPath Pathway	TCR Signaling Pathway
	TNFalpha Signaling Pathway
PANTHER Pathway	Angiogenesis
	VEGF signaling pathway
Pathway Interaction Database	Fc-epsilon receptor I signaling in mast cells
	Beta3 integrin cell surface interactions
	S1P1 pathway
	Sphingosine 1-phosphate (S1P) pathway
	PDGFR-beta signaling pathway
Reactome	Sphingolipid de novo biosynthesis
	VEGFR2 mediated cell proliferation
WikiPathways	Signal Transduction of S1P Receptor
	Protein folding
	Sphingolipid Metabolism
References
Ref 525833	F-12509A, a new sphingosine kinase inhibitor, produced by a discomycete. J Antibiot (Tokyo). 2000 May;53(5):459-66.
Ref 525833	F-12509A, a new sphingosine kinase inhibitor, produced by a discomycete. J Antibiot (Tokyo). 2000 May;53(5):459-66.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.