Drug Information

Drug General Information
Drug ID
D0P0YD
Former ID
DIB002818
Drug Name
TNF-targeting small molecule therapeutic, oral, inflammation/autoimmune disease
Synonyms
TNF-targeting small molecule therapeutic (oral, inflammation/autoimmune disease)
Indication Autoimmune diabetes [ICD10:E08-E13] Investigative [527270]
Company
Ception Therapeutics Inc
Target and Pathway
Target(s) Tumour necrosis factor receptor-1 (TNFR1) Target Info Modulator [527270]
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
NF-kappa B signaling pathway
Sphingolipid signaling pathway
Apoptosis
Osteoclast differentiation
TNF signaling pathway
Adipocytokine signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Influenza A
HTLV-I infection
Herpes simplex infection
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
Pathway Interaction Database Canonical NF-kappaB pathway
Signaling events mediated by HDAC Class I
TNF receptor signaling pathway
Ceramide signaling pathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Caspase Cascade in Apoptosis
Reactome TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR1-mediated ceramide production
TNFs bind their physiological receptors
TNF signaling
WikiPathways Inflammatory Response Pathway
Apoptosis Modulation by HSP70
Cardiac Hypertrophic Response
Apoptosis
Nanoparticle triggered regulated necrosis
Amyotrophic lateral sclerosis (ALS)
Integrated Pancreatic Cancer Pathway
TNF alpha Signaling Pathway
Alzheimers Disease
Extrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
References
Ref 527270Secretion of a TNFR:Fc fusion protein following pulmonary administration of pseudotyped adeno-associated virus vectors. J Virol. 2004 Nov;78(22):12355-65.
Ref 527270Secretion of a TNFR:Fc fusion protein following pulmonary administration of pseudotyped adeno-associated virus vectors. J Virol. 2004 Nov;78(22):12355-65.

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