Drug General Information
Drug ID	D0P1IX
Former ID	DIB005485
Drug Name	OT-551
Synonyms	Tempol-H prodrug, Othera
Drug Type	Small molecular drug
Indication	Ocular inflammation [ICD9: 370.33; ICD10:H16.229]		Phase 2	[521815]
Company	Othera Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Formula	C13H23NO3
Canonical SMILES	CC1(C)CC(CC(C)(C)N1O)OC(=O)C1CC1.Cl
PubChem Compound ID	10131000
Target and Pathway
Target(s)	Nuclear factor erythroid 2-related factor 2	Target Info	Inhibitor	[532414]
KEGG Pathway	Protein processing in endoplasmic reticulum
NetPath Pathway	IL5 Signaling Pathway
WikiPathways	Oxidative Stress
	Transcriptional activation by NRF2
	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Aryl Hydrocarbon Receptor Pathway
	Mesodermal Commitment Pathway
	Aryl Hydrocarbon Receptor
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	Arylhydrocarbon receptor (AhR) signaling pathway
References
Ref 521815	ClinicalTrials.gov (NCT00306488) OT-551 Antioxidant Eye Drops to Treat Geographic Atrophy in Age-Related Macular Degeneration. U.S. National Institutes of Health.
Ref 532414	New hope for dry AMD. Nat Rev Drug Discov. 2013 Jul;12(7):501-2.

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