Drug General Information
Drug ID	D0Q7AG
Former ID	DIB002475
Drug Name	CGM097
Indication	Late-stage solid tumors [ICD9: 140-199, 210-229; ICD10:C00-C75, C7A, C7B, D10-D36, D3A]		Phase 1	[524175]
Company	Novartis pharmaceuticals
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Cellular tumor antigenp53	Target Info	Modulator	[1572591]
KEGG Pathway	MAPK signaling pathway
	Sphingolipid signaling pathway
	Cell cycle
	p53 signaling pathway
	PI3K-Akt signaling pathway
	Apoptosis
	Wnt signaling pathway
	Neurotrophin signaling pathway
	Thyroid hormone signaling pathway
	Amyotrophic lateral sclerosis (ALS)
	Huntington's disease
	Hepatitis C
	Hepatitis B
	Measles
	HTLV-I infection
	Herpes simplex infection
	Epstein-Barr virus infection
	Pathways in cancer
	Transcriptional misregulation in cancer
	Viral carcinogenesis
	Proteoglycans in cancer
	MicroRNAs in cancer
	Colorectal cancer
	Pancreatic cancer
	Endometrial cancer
	Glioma
	Prostate cancer
	Thyroid cancer
	Basal cell carcinoma
	Melanoma
	Bladder cancer
	Chronic myeloid leukemia
	Small cell lung cancer
	Non-small cell lung cancer
	Central carbon metabolism in cancer
NetPath Pathway	FSH Signaling Pathway
PANTHER Pathway	Apoptosis signaling pathway
	Huntington disease
	Wnt signaling pathway
	p53 pathway
	P53 pathway feedback loops 1
	p53 pathway by glucose deprivation
	p53 pathway feedback loops 2
Pathway Interaction Database	Signaling events mediated by HDAC Class III
	Validated targets of C-MYC transcriptional activation
	LKB1 signaling events
	Glucocorticoid receptor regulatory network
	Direct p53 effectors
	p75(NTR)-mediated signaling
	AP-1 transcription factor network
	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
	Signaling mediated by p38-alpha and p38-beta
	Aurora A signaling
	BARD1 signaling events
	p53 pathway
	PLK3 signaling events
Reactome	Activation of NOXA and translocation to mitochondria
	Activation of PUMA and translocation to mitochondria
	Pre-NOTCH Transcription and Translation
	Oxidative Stress Induced Senescence
	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
	Oncogene Induced Senescence
	DNA Damage/Telomere Stress Induced Senescence
	Autodegradation of the E3 ubiquitin ligase COP1
	TP53 Regulates Metabolic Genes
	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
	Stabilization of p53
	Factors involved in megakaryocyte development and platelet production
WikiPathways	DNA Damage Response (only ATM dependent)
	DNA Damage Response
	ErbB Signaling Pathway
	Senescence and Autophagy in Cancer
	G1 to S cell cycle control
	Sandbox Pathway
	Wnt Signaling Pathway and Pluripotency
	MAPK Signaling Pathway
	TGF beta Signaling Pathway
	Copper homeostasis
	Bladder Cancer
	Mammary gland development pathway - Involution (Stage 4 of 4)
	Pre-NOTCH Expression and Processing
	Apoptosis
	ATM Signaling Pathway
	Amyotrophic lateral sclerosis (ALS)
	Retinoblastoma (RB) in Cancer
	Spinal Cord Injury
	Integrated Pancreatic Cancer Pathway
	Oncostatin M Signaling Pathway
	Gastric cancer network 2
	Prostate Cancer
	Signaling Pathways in Glioblastoma
	Metastatic brain tumor
	Alzheimers Disease
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Intrinsic Pathway for Apoptosis
	Factors involved in megakaryocyte development and platelet production
	Cell Cycle
	Cell Cycle Checkpoints
	Apoptosis Modulation and Signaling
	Folate Metabolism
	TP53 Network
	Fluoropyrimidine Activity
	miRNAs involved in DNA damage response
	miRNA Regulation of DNA Damage Response
	AMPK Signaling
References
Ref 524175	ClinicalTrials.gov (NCT01760525) A Phase I Dose Escalation Study of CGM097 in Adult Patients With Selected Advanced Solid Tumors. U.S. National Institutes of Health.
Ref 1572591	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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