Drug Information

Drug General Information
Drug ID
D0QI6W
Former ID
DIB003308
Drug Name
Non-peptide TPO mimics
Synonyms
Non-peptide TPO mimics (thrombocytopenia); Non-peptide TPO mimics (thrombocytopenia), Shanghai Hengrui
Indication Thrombocytopenia [ICD9: 287.3, 287.4, 287.5; ICD10:D69.6, P61.0] Investigative [543468]
Company
Shanghai Hengrui Pharmaceutical Co Ltd
Structure
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2D MOL

3D MOL
Canonical SMILES
c1(C(=O)O)ccc2N(CCc2c1)C(=O)NN/C(=C/1\C(=NN(C1=O)c1ccc2<br />c(c1)CCC2)C)/C
Target and Pathway
Target(s) Thrombopoietin Receptor Target Info Modulator [543468]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
WikiPathways Platelet Aggregation (Plug Formation)
References
Ref 543468(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722).
Ref 543468(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722).

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