Drug Information

Drug General Information
Drug ID
D0R4OD
Former ID
DIB014119
Drug Name
Anti-IFN gamma
Synonyms
AGT-1; Anti-IFN gamma (autoimmune diseases); Anti-cytokine antibodies, Advanced Biotherapy; Anti-cytokine therapy, Advanced Biotherapy; Anti-IFN gamma (autoimmune diseases), Advanced Biotherapy
Drug Type
Antibody
Indication Alopecia [ICD9: 704.09; ICD10:L65.9] Terminated [546358]
Company
Advanced Biotherapy Inc
CAS Number
CAS 316350-99-9
Target and Pathway
Target(s) Tumour necrosis factor receptor-1 (TNFR1) Target Info [527270]
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
NF-kappa B signaling pathway
Sphingolipid signaling pathway
Apoptosis
Osteoclast differentiation
TNF signaling pathway
Adipocytokine signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Influenza A
HTLV-I infection
Herpes simplex infection
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
Pathway Interaction Database Canonical NF-kappaB pathway
Signaling events mediated by HDAC Class I
TNF receptor signaling pathway
Ceramide signaling pathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Caspase Cascade in Apoptosis
Reactome TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR1-mediated ceramide production
TNFs bind their physiological receptors
TNF signaling
WikiPathways Inflammatory Response Pathway
Apoptosis Modulation by HSP70
Cardiac Hypertrophic Response
Apoptosis
Nanoparticle triggered regulated necrosis
Amyotrophic lateral sclerosis (ALS)
Integrated Pancreatic Cancer Pathway
TNF alpha Signaling Pathway
Alzheimers Disease
Extrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
References
Ref 546358Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007694)
Ref 527270Secretion of a TNFR:Fc fusion protein following pulmonary administration of pseudotyped adeno-associated virus vectors. J Virol. 2004 Nov;78(22):12355-65.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.