Drug Information

Drug General Information
Drug ID
D0R8HY
Former ID
DNCL003121
Drug Name
DCCCyB
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Phase 1 [548843]
Company
Merck
Structure
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2D MOL

3D MOL
Formula
C22H29Cl2NO3S
Canonical SMILES
C1CC1CC2(CCC(CC2)S(=O)(=O)CC3CC3)CNC(=O)C4=C(C=C(C=C4)C<br />l)Cl
InChI
1S/C22H29Cl2NO3S/c23-17-5-6-19(20(24)11-17)21(26)25-14-22(12-15-1-2-15)9-7-18(8-10-22)29(27,28)13-16-3-4-16/h5-6,11,15-16,18H,1-4,7-10,12-14H2,(H,25,26)
InChIKey
PSIMLOLEQCVVJV-UHFFFAOYSA-N
PubChem Compound ID
15951941
PubChem Substance ID
22423386, 26558191, 33334867, 50134574, 57304430, 104220237, 138029144, 163326579, 163340781, 172918234, 226973725, 245781528
Target and Pathway
Target(s) Sodium- and chloride-dependent glycine transporter 1 Target Info Modulator [544400]
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways NRF2 pathway
References
Ref 548843Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029447)
Ref 544400Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1. ACS Med Chem Lett. 2010 October 14; 1(7): 350-354.

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