Drug General Information
Drug ID	D0S7UQ
Former ID	DIB010344
Drug Name	RG-7103
Synonyms	R-7103; RO-5024118; VPAC2 agonist (COPD), Roche
Indication	Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47]		Phase 1	[522843]
Company	F Hoffmann-La Roche Ltd
Structure		Download 2D MOL
Target and Pathway
Target(s)	VIP 2 receptor	Target Info	Agonist	[548713]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
NetPath Pathway	TCR Signaling Pathway
Reactome	G alpha (s) signalling events
WikiPathways	SIDS Susceptibility Pathways
	GPCRs, Class B Secretin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522843	ClinicalTrials.gov (NCT01009424) A Multi-center Study to Investigate the Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of R7103 Following Repeated Inhalation in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease. U.S. National Institutes of Health.
Ref 548713	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027925)

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