Drug Information

Drug General Information
Drug ID
D0TZ5E
Former ID
DIB007990
Drug Name
Glycine type-1 transporter inhibitors
Synonyms
Glycine type-1 transporter inhibitors (psychosis); Glycine type-1 transporter inhibitors (psychosis), EGIS
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Investigative [552153]
Company
EGIS Gyogyszergyar RT
Structure
Download
2D MOL

3D MOL
Canonical SMILES
c1(ccc(cc1)C(Oc1ccc(cc1)OC1=CC(=O)C(N=C1)C)CCN(CC(=O)[O<br />-])C)F.[Li+]
Target and Pathway
Target(s) Sodium- and chloride-dependent glycine transporter 1 Target Info Inhibitor [543979]
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways NRF2 pathway
References
Ref 552153US patent application no. 4525358, 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids and their amides.
Ref 543979(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 935).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.