Drug Information

Drug General Information
Drug ID
D0U2DY
Former ID
DIB004239
Drug Name
Recombinant TSH superagonists
Synonyms
Recombinant TSH superagonists (thyroid cancer); TR-1401; TR-1402; Recombinant TSH superagonists (thyroid cancer), Trophogen; TSH superagonist (thyroid cancer/goiter), Trophogen; Thyroid stimulating hormone superagonist (thyroid cancer/goiter), Trophogen
Indication Thyroid cancer [ICD9: 140-229, 193; ICD10:C73] Investigative [543645]
Company
Trophogen Inc
Target and Pathway
Target(s) Thyrotropin receptor Target Info Agonist [543645]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Thyroid hormone synthesis
Autoimmune thyroid disease
NetPath Pathway Wnt Signaling Pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Hormone ligand-binding receptors
G alpha (s) signalling events
WikiPathways Peptide GPCRs
TSH signaling pathway
Thyroxine (Thyroid Hormone) Production
GPCR ligand binding
GPCR downstream signaling
References
Ref 543645(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 255).
Ref 543645(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 255).

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