Drug Information

Drug General Information
Drug ID
D0U3RV
Former ID
DIB004607
Drug Name
Motexafin lutetium
Synonyms
Lutetium texaphyrin; Lu-Tex; Motexafin lutetium < USAN; Optrin (Pharmacyclics); PCI-0123; Prop INNM >; Antrin (Pharmacyclics, US, US); Lutrin (National Cancer Institute (US), US; Pharmacyclics, , , JP); (PB-7-11-233'2'4)-Bis(acetato-O)[9,10-diethyl-20,21-bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-4,15-dimethyl-8,11-imino-3,6:16,13-dinitrilo-1,18-benzodiazacycloeicosine-5,14-dipropanolato-N1,N18,N23,N24
Drug Type
Small molecular drug
Indication Restenosis [ICD10:I51.89] Phase 3 [529626]
Company
Pharmacyclics
Structure
Download
2D MOL

3D MOL
Formula
C52H74LuN5O15
Canonical SMILES
CCC1=C(C2=CC3=NC(=CN=C4C=C(C(=CC4=NC=C5C(=C(C(=N5)C=C1[<br />N-]2)CCCO)C)OCCOCCOCCOC)OCCOCCOCCOC)C(=C3CCCO)C)CC.CC(=<br />O)[O-].CC(=O)[O-].O.[Lu+3]
InChI
1S/C48H66N5O10.2C2H4O2.Lu.H2O/c1-7-35-36(8-2)40-28-42-38(12-10-14-55)34(4)46(53-42)32-50-44-30-48(63-26-24-61-22-20-59-18-16-57-6)47(62-25-23-60-21-19-58-17-15-56-5)29-43(44)49-31-45-33(3)37(11-9-13-54)41(52-45)27-39(35)51-40;2*1-2(3)4;;/h27-32,54-55H,7-26H2,1-6H3;2*1H3,(H,3,4);;1H2/q-1;;;+3;/p-2
InChIKey
WIQKYZYFTAEWBF-UHFFFAOYSA-L
PubChem Compound ID
3081907
PubChem Substance ID
36412598, 50070531, 74406480, 111683936, 135229126, 137267641, 164763176, 198986346
Target and Pathway
Target(s) Prostate specific antigen Target Info Modulator [529626]
KEGG Pathway Pathways in cancer
Prostate cancer
Pathway Interaction Database Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
FOXA1 transcription factor network
Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways Prostate Cancer
Androgen receptor signaling pathway
References
Ref 529626Motexafin lutetium-photodynamic therapy of prostate cancer: short- and long-term effects on prostate-specific antigen. Clin Cancer Res. 2008 Aug 1;14(15):4869-76.
Ref 529626Motexafin lutetium-photodynamic therapy of prostate cancer: short- and long-term effects on prostate-specific antigen. Clin Cancer Res. 2008 Aug 1;14(15):4869-76.

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