Drug General Information
Drug ID	D0U5BF
Former ID	DIB008446
Drug Name	ALPHA-FMH
Synonyms	Alpha-(Fluoromethyl)histidine
Drug Type	Small molecular drug
Indication	Pruritus [ICD9: 698; ICD10:L29]		Phase 1	[468247]
Structure		Download 2D MOL 3D MOL
Formula	C7H10FN3O2
InChI	InChI=1S/C7H10FN3O2/c8-3-7(9,6(12)13)1-5-2-10-4-11-5/h2,4H,1,3,9H2,(H,10,11)(H,12,13)
InChIKey	AJFGLTPLWPTALJ-UHFFFAOYSA-N
CAS Number	CAS 70050-43-0
PubChem Compound ID	107653
PubChem Substance ID	10234370, 14891902, 44436635, 49979917, 50622637, 57338163, 103852680, 104379411, 117543345, 125659529, 125816903, 127414567, 132513148, 135256518, 163176686, 163178087, 178101877, 224835923, 226442401, 236374287, 252671122
Target and Pathway
Target(s)	Histidine decarboxylase	Target Info	Modulator	[532504]
KEGG Pathway	Histidine metabolism
	Metabolic pathways
PANTHER Pathway	Histamine synthesis
	CCKR signaling map ST
PathWhiz Pathway	Histidine Metabolism
WikiPathways	Biogenic Amine Synthesis
	Metabolism of amino acids and derivatives
References
Ref 468247	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5189).
Ref 532504	Alpha-Fluoromethylhistidine. Kinetics of uptake and inhibition of histamine synthesis in basophil (2H3) cell cultures. Mol Pharmacol. 1985 Aug;28(2):191-9.

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