Drug General Information
Drug ID	D0U5NY
Former ID	DIB016581
Drug Name	JTT-553
Synonyms	DGAT1 inhibitor (oral, obesity) Japan Tobacco
Indication	Obesity [ICD9: 278; ICD10:E66]		Discontinued in Phase 1	[548598]
Company	Japan Tobacco Inc
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Diglyceride acyltransferase	Target Info	Inhibitor	[533317]
BioCyc Pathway	Triacylglycerol biosynthesis
KEGG Pathway	Glycerolipid metabolism
	Retinol metabolism
	Metabolic pathways
	Fat digestion and absorption
PathWhiz Pathway	Retinol Metabolism
Reactome	Acyl chain remodeling of DAG and TAG
	Triglyceride Biosynthesis
WikiPathways	Vitamin A and Carotenoid Metabolism
	Statin Pathway
	Triacylglyceride Synthesis
	Glycerophospholipid biosynthesis
	Fatty acid, triacylglycerol, and ketone body metabolism
References
Ref 548598	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026874)
Ref 533317	JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice. J Pharmacol Sci. 2015 Sep;129(1):51-8.

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