Drug Information

Drug General Information
Drug ID
D0V1SA
Drug Name
FANG vaccine
Synonyms
Bi-shRNAfurin; TAG vaccine; TGFbeta2 antisense + rhGMCSF vaccine; Vigil
Indication Ovarian cancer [ICD9: 183; ICD10:C56] Phase 2/3 [531742]
Therapeutic Class
Anticancer Agents
Target and Pathway
Target(s) Transforming growth factor beta 2 Target Info Modulator [531742]
Granulocyte-macrophage colony-stimulating factor Target Info Modulator [531742]
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
FoxO signaling pathway
Cell cycle
Endocytosis
TGF-beta signaling pathway
Osteoclast differentiation
Hippo signaling pathway
Leishmaniasis
Chagas disease (American trypanosomiasis)
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
HTLV-I infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Chronic myeloid leukemia
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
Hypertrophic cardiomyopathy (HCM)
Dilated cardiomyopathyhsa04060:Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Hematopoietic cell lineage
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Salmonella infection
Transcriptional misregulation in cancer
NetPath Pathway TCR Signaling Pathway
EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TNFalpha Signaling PathwayNetPath_13:IL1 Signaling Pathway
IL2 Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway TGF-beta signaling pathway
Pathway Interaction Database Glypican 1 network
ATF-2 transcription factor network
Signaling events mediated by the Hedgehog family
Regulation of retinoblastoma protein
TGF-beta receptor signalinggmcsf_pathway:GMCSF-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Glucocorticoid receptor regulatory network
Alpha9 beta1 integrin signaling events
AP-1 transcription factor network
Calcium signaling in the CD4+ TCR pathway
Syndecan-2-mediated signaling events
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
Reactome Platelet degranulation
Molecules associated with elastic fibres
ECM proteoglycansR-HSA-114604:GPVI-mediated activation cascade
G beta:gamma signalling through PI3Kgamma
Interleukin-3, 5 and GM-CSF signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling
WikiPathways Endochondral Ossification
p38 MAPK Signaling Pathway
MAPK Signaling Pathway
NRF2 pathway
Nuclear Receptors Meta-Pathway
Vitamin D Receptor Pathway
Extracellular vesicle-mediated signaling in recipient cells
Extracellular matrix organization
Elastic fibre formationWP530:Cytokines and Inflammatory Response
Hematopoietic Stem Cell Differentiation
Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
References
Ref 531742Phase I trial of "bi-shRNAi(furin)/GMCSF DNA/autologous tumor cell" vaccine (FANG) in advanced cancer. Mol Ther. 2012 Mar;20(3):679-86.
Ref 531742Phase I trial of "bi-shRNAi(furin)/GMCSF DNA/autologous tumor cell" vaccine (FANG) in advanced cancer. Mol Ther. 2012 Mar;20(3):679-86.

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