Drug General Information
Drug ID
D0V3HC
Former ID
DIB005948
Drug Name
Anti-CD40-XTEN
Synonyms
CD40 ligand receptor antagonist (XTEN, rheumatoid arthritis/transplant rejection), Amunix
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Investigative [543514]
Company
Amunix Inc
Target and Pathway
Target(s) Tumor necrosisfactor receptor superfamily member 5 Target Info Antagonist [543514]
KEGG Pathway Cytokine-cytokine receptor interaction
NF-kappa B signaling pathway
Cell adhesion molecules (CAMs)
Toll-like receptor signaling pathway
Intestinal immune network for IgA production
Malaria
Toxoplasmosis
HTLV-I infection
Epstein-Barr virus infection
Transcriptional misregulation in cancer
Asthma
Autoimmune thyroid disease
Systemic lupus erythematosus
Allograft rejection
Primary immunodeficiency
Viral myocarditis
Pathway Interaction Database CD40/CD40L signaling
WikiPathways Toll-like receptor signaling pathway
Inflammatory Response Pathway
NLR Proteins
Vitamin D Receptor Pathway
Human Complement System
Allograft Rejection
Regulation of toll-like receptor signaling pathway
References
Ref 543514(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1874).
Ref 543514(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1874).

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