Drug Information

Drug General Information
Drug ID
D0V3LM
Former ID
DIB000541
Drug Name
P54
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 2 [551802]
Target and Pathway
Target(s) Nuclear factor kappa B p105 subunit Target Info Modulator [527663]
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Sphingolipid signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Osteoclast differentiation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Cytosolic DNA-sensing pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
Prolactin signaling pathway
Adipocytokine signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Cocaine addiction
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Salmonella infection
Pertussis
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Transcriptional misregulation in cancer
Viral carcinogenesis
MicroRNAs in cancer
Pancreatic cancer
Prostate cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Inflammatory bowel disease (IBD)
NetPath Pathway IL5 Signaling Pathway
IL1 Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
TNFalpha Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
T cell activation
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
BCR signaling pathway
LPA receptor mediated events
Atypical NF-kappaB pathway
Canonical NF-kappaB pathway
CD40/CD40L signaling
IL12-mediated signaling events
Alternative NF-kappaB pathway
Osteopontin-mediated events
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by HDAC Class I
Regulation of Telomerase
IL1-mediated signaling events
Glucocorticoid receptor regulatory network
TNF receptor signaling pathway
IL2 signaling events mediated by PI3K
Ceramide signaling pathway
amb2 Integrin signaling
IL23-mediated signaling events
HIV-1 Nef: Negative effector of Fas and TNF-alpha
EPO signaling pathway
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Regulated proteolysis of p75NTR
NF-kB is activated and signals survival
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Transcriptional regulation of white adipocyte differentiation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 processing
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
CD209 (DC-SIGN) signaling
CLEC7A/inflammasome pathway
MAP3K8 (TPL2)-dependent MAPK1/3 activation
TRAF6 mediated NF-kB activation
WikiPathways Toll-like receptor signaling pathway
DNA Damage Response (only ATM dependent)
SIDS Susceptibility Pathways
TCR Signaling Pathway
Notch Signaling Pathway
TGF Beta Signaling Pathway
Oxidative Stress
IL-4 Signaling Pathway
Apoptosis Modulation by HSP70
MAPK Signaling Pathway
Myometrial Relaxation and Contraction Pathways
IL1 and megakaryotyces in obesity
Apoptosis-related network due to altered Notch3 in ovarian cancer
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Hair Follicle Development: Organogenesis (Part 2 of 3)
Hair Follicle Development: Induction (Part 1 of 3)
Selenium Metabolism and Selenoproteins
Cardiac Hypertrophic Response
Cytosolic sensors of pathogen-associated DNA
Fc epsilon receptor (FCERI) signaling
Transcriptional Regulation of White Adipocyte Differentiation
Signaling by the B Cell Receptor (BCR)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Structural Pathway of Interleukin 1 (IL-1)
EBV LMP1 signaling
Aryl Hydrocarbon Receptor
T-Cell Receptor and Co-stimulatory Signaling
Apoptosis
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Corticotropin-releasing hormone
AGE/RAGE pathway
TNF alpha Signaling Pathway
B Cell Receptor Signaling Pathway
TSLP Signaling Pathway
IL17 signaling pathway
Neural Crest Differentiation
TWEAK Signaling Pathway
Leptin signaling pathway
RANKL/RANK Signaling Pathway
Integrated Breast Cancer Pathway
Signalling by NGF
IL-1 signaling pathway
TCR signaling
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Interleukin-1 signaling
Interleukin-1 processing
Apoptosis Modulation and Signaling
Folate Metabolism
TFs Regulate miRNAs related to cardiac hypertrophy
MicroRNAs in cardiomyocyte hypertrophy
Vitamin B12 Metabolism
Selenium Micronutrient Network
Regulation of toll-like receptor signaling pathway
Osteopontin Signaling
References
Ref 551802Biotechnology in Comparative Perspective, Gerhard Fuchs. Page(82).
Ref 527663Identification of p54(nrb) and the 14-3-3 Protein HS1 as TNF-alpha-inducible genes related to cell cycle control and apoptosis in human arterial endothelial cells. J Biochem Mol Biol. 2005 Jul 31;38(4):447-56.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.