Drug Information

Drug General Information
Drug ID
D0V3ZX
Former ID
DIB000596
Drug Name
DA-3607
Synonyms
Ad-stTRAIL; TRAIL adenoviral gene therapy (cancer), Dong-A
Indication Brain cancer [ICD9: 191, 225.0; ICD10:C71, D33] Phase 1 [548564]
Company
Dong-A Pharmaceutical Co Ltd
Target and Pathway
Target(s) TNF related apoptosis inducing ligand Target Info Binder [527776]
KEGG Pathway Cytokine-cytokine receptor interaction
FoxO signaling pathway
Apoptosis
Natural killer cell mediated cytotoxicity
Measles
Influenza A
NetPath Pathway IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TNFalpha Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
Pathway Interaction Database TRAIL signaling pathway
Caspase Cascade in Apoptosis
Reactome Ligand-dependent caspase activation
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signaling
WikiPathways Apoptosis
Extrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
TP53 Network
References
Ref 548564Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026657)
Ref 527776Cancer gene therapy using a novel secretable trimeric TRAIL. Gene Ther. 2006 Feb;13(4):330-8.

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