Drug Information

Drug General Information
Drug ID
D0V7YA
Former ID
DCL000120
Drug Name
GMX1777
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [530334]
Therapeutic Class
Anticancer Agents
Company
Gemin X
Structure
Download
2D MOL

3D MOL
Formula
C30H43Cl2N5O8
Canonical SMILES
COCCOCCOCCOCCOC(=O)OC[N+]1=CC=C(C=C1)NC(=NCCCCCCOC2=CC=<br />C(C=C2)Cl)NC#N.[Cl-]
InChI
1S/C30H42ClN5O8.ClH/c1-38-16-17-39-18-19-40-20-21-41-22-23-43-30(37)44-25-36-13-10-27(11-14-36)35-29(34-24-32)33-12-4-2-3-5-15-42-28-8-6-26(31)7-9-28;/h6-11,13-14H,2-5,12,15-23,25H2,1H3,(H,33,34);1H
InChIKey
DAHMXVAETAAQOZ-UHFFFAOYSA-N
PubChem Compound ID
9961434
PubChem Substance ID
14937250, 46058025, 77152635, 103461535, 124490418, 125749169, 134338805, 135262321, 144227834, 162527759, 184531185, 184811884, 198976913, 228761575
Target and Pathway
Target(s) Nicotinamide phosphoribosyltransferase Target Info Modulator [530334]
BioCyc Pathway NAD salvage
KEGG Pathway Nicotinate and nicotinamide metabolism
Metabolic pathways
NetPath Pathway IL2 Signaling Pathway
IL1 Signaling Pathway
TCR Signaling Pathway
PathWhiz Pathway Nicotinate and Nicotinamide Metabolism
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
WikiPathways Adipogenesis
Metabolism of water-soluble vitamins and cofactors
Circadian Clock
References
Ref 530334Mol Cell Biol. 2009 Nov;29(21):5872-88. Epub 2009 Aug 24.The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors.
Ref 530334Mol Cell Biol. 2009 Nov;29(21):5872-88. Epub 2009 Aug 24.The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors.

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