Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0V8AG
|
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| Former ID |
DNCL002577
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| Drug Name |
Poly-ICLC
|
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| Drug Type |
Small molecular drug
|
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| Indication | Glioblastoma multiforme [ICD9: 191; ICD10:C71] | Phase 2 | [528669] | ||
| Company |
Oncovir
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C25H41N9O18P2
|
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| Canonical SMILES |
C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2<br />=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O.C(CCN)CC(C(=O)O<br />)N
|
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| InChI |
1S/C10H13N4O8P.C9H14N3O8P.C6H14N2O2/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;7-4-2-1-3-5(8)6(9)10/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18);5H,1-4,7-8H2,(H,9,10)
|
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| InChIKey |
USXNNSPLVOYHFZ-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Toll-like receptor 3 | Target Info | Inducer | [528669] | |
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Toll receptor signaling pathway | ||||
| Pathway Interaction Database | Endogenous TLR signaling | ||||
| Reactome | Ligand-dependent caspase activation | ||||
| MyD88-independent TLR3/TLR4 cascade | |||||
| Trafficking and processing of endosomal TLR | |||||
| RIP-mediated NFkB activation via ZBP1 | |||||
| TRIF-mediated programmed cell death | |||||
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | |||||
| IKK complex recruitment mediated by RIP1 | |||||
| TRAF6 mediated induction of TAK1 complex | |||||
| References | |||||
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