Drug Information

Drug General Information
Drug ID
D0W8WB
Former ID
DNC000303
Drug Name
Berberine
Drug Type
Small molecular drug
Indication Discovery agent Phase 4 [524081]
Structure
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2D MOL

3D MOL
Formula
C20H18NO4+
Canonical SMILES
COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC
InChI
1S/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-10H,5-6,11H2,1-2H3/q+1
InChIKey
YBHILYKTIRIUTE-UHFFFAOYSA-N
CAS Number
CAS 2086-83-1
PubChem Compound ID
2353
PubChem Substance ID
4019, 598412, 841172, 5424490, 5424491, 5609012, 7886143, 7927271, 8145003, 8151578, 10513274, 11112431, 11335440, 11360679, 11364004, 11366566, 11369128, 11371756, 11374369, 11377290, 11405445, 11405619, 11408710, 11447002, 11461651, 11466614, 11467734, 11484444, 11486387, 11488710, 11490434, 11492600, 11494924, 11537739, 12146010, 14777746, 22390066, 22391440, 26753128, 29221521, 33889979, 46487939, 46506051, 47365076, 47515214, 47515215, 47515216, 47662167, 47736364, 47810644
ChEBI ID
ChEBI:16118
Target and Pathway
Target(s) Telomerase reverse transcriptase Target Info Inhibitor [535389]
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Validated targets of C-MYC transcriptional activation
Regulation of Telomerase
IL2 signaling events mediated by PI3K
Regulation of nuclear beta catenin signaling and target gene transcription
HIF-1-alpha transcription factor network
Reactome Formation of the beta-catenin:TCF transactivating complex
References
Ref 524081ClinicalTrials.gov (NCT01697735) The Therapeutic Effects of Statins and Berberine on the Hyperlipemia. U.S. National Institutes of Health.
Ref 535389Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine. Parasitol Int. 2002 Mar;51(1):99-103.

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