Drug General Information
Drug ID	D0X0PP
Former ID	DNCL003117
Drug Name	AMG 579
Indication	Schizoaffective disorder; Schizophrenia [ICD9: 295, 295.70; ICD10:F20, F25]		Phase 1	[549374]
Company	Amgen
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Phosphodiesterase 10A (PDE10A)	Target Info	Inhibitor	[532898]
KEGG Pathway	Purine metabolism
	Morphine addiction
PathWhiz Pathway	Purine Metabolism
Reactome	cGMP effects
	G alpha (s) signalling events
References
Ref 549374	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035904)
Ref 532898	Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase10A (PDE10A). J Med Chem. 2014 Aug 14;57(15):6632-41.

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