Drug Information

Drug General Information
Drug ID
D0XI2Z
Former ID
DNC001144
Drug Name
PPA
Indication Discovery agent Investigative [535961]
Structure
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2D MOL

3D MOL
Canonical SMILES
CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OP(=O)(O)O)OC(=O)CCCC<br />CCCC=CCCCCCCCC
InChI
1S/C37H72O11P2/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-37(39)47-35(34-46-50(43,44)48-49(40,41)42)33-45-36(38)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h17-18,35H,3-16,19-34H2,1-2H3,(H,43,44)(H2,40,41,42)/b18-17-/t35-/m1/s1
InChIKey
KGPOTEGAEDLRDC-QEJMHMKOSA-N
CAS Number
CAS 36393-57-4
PubChem Substance ID
46508087
Target and Pathway
Target(s) Telomerase reverse transcriptase Target Info Inhibitor [535961]
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Validated targets of C-MYC transcriptional activation
Regulation of Telomerase
IL2 signaling events mediated by PI3K
Regulation of nuclear beta catenin signaling and target gene transcription
HIF-1-alpha transcription factor network
Reactome Formation of the beta-catenin:TCF transactivating complex
References
Ref 535961Growth arrest, apoptosis, and telomere shortening of Barrett's-associated adenocarcinoma cells by a telomerase inhibitor. Gastroenterology. 2004 May;126(5):1337-46.
Ref 535961Growth arrest, apoptosis, and telomere shortening of Barrett's-associated adenocarcinoma cells by a telomerase inhibitor. Gastroenterology. 2004 May;126(5):1337-46.

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